12-Month Real-Life Efficacy of the MiniMed 780G Advanced Closed-Loop System in Patients Living with Type 1 Diabetes: A French Observational, Retrospective, Multicentric Study
Main finding · TIRResult — go to the resultChange +9.1 % 95% CI 7.6–10.5Authors' conclusion
After 1 year of use of AHCL, people living with T1D safely improved their glucose control and a higher proportion of them achieved optimal glycemic control.
Study context
- Population
- Patients living with T1D using the MiniMed 780G advanced hybrid closed-loop (AHCL) system, 20 centers in France200 analysed
- Participants
- 220 patients
- Exposure
- After 1 year of AHCL use vs pre-AHCL
- Outcome
- Variation of time in range (TIR) between pre-AHCL and after 1-year use of AHCL
- Follow-up
- 1 year
Methodological detailsmulticentric, 20 centers in France, pre-post comparison
- Multicentric
- 20 centers in France
- Pre-post comparison
Main finding
TIR
Change
+9.1 %
95% CI 7.6–10.5
P < 0.001
By group
AHCL 1 year
72.5
mean · ± 10.6% · %
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | AHCL 1 year | Pre-AHCL | Change (%) (95% CI) | P value | |
|---|---|---|---|---|---|
| HbA1c · 1 year | mean 7.1 ± 0.7% % | — not stated in the abstract | −0.5 (−0.6 to −0.4) | P < 0.001 | |
| TAR · 1 year | mean 24.8 ± 10.9% % | — not stated in the abstract | −7.3 (−8.8 to −5.7) | P < 0.001 | |
| −10−505Difference, % (linear scale) |
— not stated in the abstract
HbA1c <7.0% · 1 year
P < 0.001
TIR >70% · 1 year
P < 0.001
| Outcome | AHCL 1 year | Pre-AHCL | Change (%) | P value |
|---|---|---|---|---|
| TBR · 1 yearSpread [−2.0; 0.0] | 2.0 (IQR 1.0–3.0) % | — not stated in the abstract | 0.0 | P < 0.001 |
— not stated in the abstract
Continued AHCL use
- Patients continuing to use AHCL
- 92.7%
Safety
- Patients with severe hypoglycemia events
- 5
- Patients with ketoacidosis
- 2
Original publication
12-Month Real-Life Efficacy of the MiniMed 780G Advanced Closed-Loop System in Patients Living with Type 1 Diabetes: A French Observational, Retrospective, Multicentric Study. Diabetes Technol Ther. Published 7 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →